The article describes in detail the history and development of knowledge about venous pathology in ancient Greece and Byzantium. Lower limb vein disease is one of the most common health problems in the world have been trying to solve for centuries. In ancient Greek medical literature, there are many reports of vein diseases and especially varicose veins. This fact allows us to understand that the veins were an instrument that was particularly worried by doctors of Antiquity and Byzantium, and that varicose veins were one of the main problems of that time, and therefore doctors used different methods and approaches in the treatment of vein diseases. The contribution of healers of antiquity to the emergence and development of modern phlebology is reflected. This disease was tried to be cured by prominent figures of antiquity and the Byzantine Empire in the field of medicine, such as Hippocrates,
Galen, Oribasius, Paul Aeginsky and others. The discoveries in the field of anatomy and pathology of the venous system are described in detail. Conservative methods are described, as well as the first vein surgeries, precursors of modern surgical interventions that were unique for that time and are still relevant today.
Keywords: history, phlebology, ancient Greece, Byzantium, varicose veins, outstanding physicians of antiquity, history of treatment of varicose veins